RyR Autoantibody Test

Test Code

The recommended alternative is ABCC8 (CHI) DNA Sequencing Test.

Test Details

Test code: 1481
Type of disorder: Neuromuscular Disorders
Disease(s) tested for: Myasthenia Gravis (MG)

Technical Information

Clinical Significance: Detects anti-RyR (ryanodine receptor) in the sera of patients with Myasthenia Gravis (MG). Other striational antibodies, such as titin, are rarely found in acetylcholine receptor (AChR) antibody-negative MG. Anti-titin is detected in 20% to 40% of all MG patients and anti-RyR in 13% to 38%. Anti-titin (49% to 95%) and anti-RyR (70% to 80%) are frequently found in thymoma associated-MG cases.
Methodology: Western Blot
Reference Range: <1:8000

CPT Coding

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

CPT: 84181

Specimen Requirements

Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.

Specimen Type: Serum
Specimen Stability: Room temperature: 72 hours, Refrigerated: 28 days, Frozen: 28 days

Shipping Considerations

Transport Temperature: Refrigerated
Set-up/Analytic Time: 7-14 days

Additional Resources

Letters of Medical Necessity

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