LRP4 Autoantibody Test

Test Code

The recommended alternative is ABCC8 (CHI) DNA Sequencing Test.

Test Details

Test code: 1483
Type of disorder: Neuromuscular Disorders
Disease(s) tested for: Myasthenia Gravis (MG)
Profiles that contain this test:

Technical Information

Clinical Significance: Detects anti-LRP4 (low density lipoprotein receptor-related protein 4) in the sera of patients with Myasthenia Gravis (MG). The LRP4 protein activates MuSK kinase activity and promotes the clustering of AChR and their stabilization at the NMJ. Anti-LRP4 antibodies are found in approximately 9.2% (range 2% to 50%) of MG patients who are negative for both anti-AChR and anti-MuSK.
Methodology: Immunofluorescence Assay (IFA)
Reference Range: See Laboratory Report

CPT Coding

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

CPT: 86255

Specimen Requirements

Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.

Specimen Type: Serum
Specimen Stability: Room temperature: 72 hours, Refrigerated: 25 days, Frozen: 25 days

Shipping Considerations

Transport Temperature: Refrigerated
Set-up/Analytic Time: 7-14 days

Additional Resources

Letters of Medical Necessity

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